Document Detail


Further evidence for the lack of association between acetylator phenotype and systemic lupus erythematosus.
MedLine Citation:
PMID:  3707628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An association between host acetylator phenotype and idiopathic systemic lupus erythematosus (SLE) has been sought for over a decade, without a definitive result. We have observed that the frequency of the slow acetylator phenotype was similar in 64 patients with idiopathic SLE (38%), 60 healthy volunteers (50%), and 52 non-SLE medical service patients (44%). The slow acetylator phenotype was not more frequent among subgroups of the SLE patients defined by demographic features or specific manifestations of disease. Our results, as well as a majority of previously published results, do not provide evidence for an association between acetylator phenotype and idiopathic SLE.
Authors:
A N Baer; R L Woosley; T Pincus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  29     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-05-28     Completed Date:  1986-05-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  508-14     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylation
Adolescent
Adult
Aged
Child
Dapsone / diagnostic use
Female
Humans
Lupus Erythematosus, Systemic / genetics*
Male
Middle Aged
Phenotype
Grant Support
ID/Acronym/Agency:
5M01RR00095/RR/NCRR NIH HHS; AM-22071/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
80-08-0/Dapsone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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