Document Detail

Further evidence of a decorin-collagen interaction in the disruption of cervical collagen fibers during rat gestation.
MedLine Citation:
PMID:  10764456     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to determine the histologic distribution and expression of decorin in rat cervix throughout the course of rat gestation and to correlate the findings with the known progression of collagen fiber disruption and cellular turnover in this tissue. STUDY DESIGN: Cervices from pregnant animals at 5, 11, 18, and 21 days were studied. A proteoglycan of low molecular weight, decorin, was detected by sensitive and specific immunohistochemical analysis with a biotin-avidin horseradish peroxidase method. RESULTS: Decorin was not detected on day 5. By day 11 moderate decorin staining was detected in the subepithelial layer and in the deep stroma. Decorin staining progressed to a strong expression in the subepithelial layer and to a moderate expression in the deep stroma on day 18. On day 21 (term in rat) the staining was fairly homogeneous throughout the connective tissue stroma. CONCLUSION: These findings clearly demonstrate that decorin expression increased progressively throughout pregnancy and are consistent with the hypothesis that an excess of decorin near term is capable of initiating a decorin-collagen interaction that leads to collagen fibril disruption and decreased cervical tensile strength.
P C Leppert; R Kokenyesi; C A Klemenich; J Fisher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  182     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-05     Completed Date:  2000-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  805-11; discussion 811-2     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, St Louis University, Missouri, USA.
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MeSH Terms
Cell Division / physiology
Cervix Uteri / cytology,  metabolism,  physiology*
Collagen / physiology*
Extracellular Matrix Proteins
Pregnancy, Animal / physiology*
Proteoglycans / metabolism,  physiology*
Tissue Distribution
Reg. No./Substance:
0/Extracellular Matrix Proteins; 0/Proteoglycans; 0/decorin; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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