Document Detail

Further evaluation of a live hepatitis A vaccine in marmosets.
MedLine Citation:
PMID:  1658214     Owner:  NLM     Status:  MEDLINE    
Live, attenuated F' hepatitis A vaccine virus was studied in vivo in Saguinus labiatus marmosets for possible reversion to virulence, for possible establishment of persistent infection and for its capacity as a parenterally administered vaccine to induce immunity to oral infection. Serial transmission of the virus in S. labiatus, using infectious stool extracts for the second and third passages, produced no evidence of reversion of the F' vaccine virus to virulence. Monitoring for live HAV in stools over a 135-day period post-inoculation of marmosets with the F' vaccine revealed no evidence of persistent infection. Vaccinated animals were also shown to be resistant to infection on challenge by the oral route as well as by the previously demonstrated parenteral route.
P J Provost; F S Banker; C W Wadsworth; D L Krah
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical virology     Volume:  34     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-12     Completed Date:  1991-12-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  227-31     Citation Subset:  IM    
Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486.
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MeSH Terms
Administration, Oral
Antigens, Viral / immunology
Callithrix / immunology
Evaluation Studies as Topic
Feces / microbiology
Hepatitis A / prevention & control*
Hepatitis A Antibodies
Hepatitis A Antigens
Hepatitis Antibodies / blood
Hepatovirus / immunology*,  pathogenicity
Infusions, Parenteral
Vaccines, Attenuated / immunology
Viral Hepatitis Vaccines / immunology*
Reg. No./Substance:
0/Antigens, Viral; 0/Hepatitis A Antibodies; 0/Hepatitis A Antigens; 0/Hepatitis Antibodies; 0/Vaccines, Attenuated; 0/Viral Hepatitis Vaccines

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