Document Detail

Further evaluation of immunocytochemical staining in the diagnosis of early myocardial ischaemic/hypoxic damage.
MedLine Citation:
PMID:  2335327     Owner:  NLM     Status:  MEDLINE    
The pattern of immunocytochemical staining with antibodies to caeruloplasmin, myosin, myoglobin and C-reactive protein seen in myocardium taken from deaths with macroscopic evidence of myocardial infarction and/or significant coronary artery atherosclerosis and from deaths with neither of these lesions has been correlated with H&E, PTAH and HBFP staining of myocardium and circumstances of each death indicative of antemortem hypoxia and/or ischaemia. Loss of staining with these antibodies correlated well with fuchsinorrhagia and both techniques are more sensitive than H&E and PTAH staining in the detection of early ischaemic/hypoxic damage to myocardium. However, their sensitivity is such that they appear to detect agonal changes and, therefore, cannot be used for specific diagnosis of early myocardial infarction.
S Leadbeatter; H M Wawman; B Jasani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Forensic science international     Volume:  45     ISSN:  0379-0738     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-06-13     Completed Date:  1990-06-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  135-41     Citation Subset:  IM    
Sub-Department of Forensic Pathology, Cardiff Royal Infirmary, U.K.
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MeSH Terms
Aged, 80 and over
Coronary Artery Disease / diagnosis*,  pathology
Middle Aged
Myocardial Infarction / diagnosis*,  pathology
Myocardium / pathology*

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