Document Detail


Further data favouring hormonal dependency of cerebral meningiomas: evidence from a patient treated with cabergoline.
MedLine Citation:
PMID:  20500108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To explore the role of cabergoline, a dopamine agonist, in the progression of meningiomas.
DESIGN: Case report.
SETTING: Teaching hospital in Barcelona, Spain (Gynecology, Obstetrics and Neonatology Clinical Institute, Hospital Clínic).
PATIENT(S): Women with a history of meningioma underwent surgery via right pterional craniotomy. During the follow-up, at 18 months after the operation the patient developed a progressive hyperprolactinemia with amenorrhea and galactorrhea. An MR examination revealed a recurrence of the neoplasm.
INTERVENTION(S): Cabergoline treatment.
MAIN OUTCOME MEASURE(S): Progression of meningioma.
RESULT(S): Long-standing cabergoline treatment in this patient with meningioma relapse early after surgery and subsequent hyperprolactinemia resulted in absence of progression of the neoplasm many years after the dopamine agonist initiation.
CONCLUSION(S): These data suggest that cabergoline, a dopamine agonist, had an antiproliferative effect on the growth of meningiomas. Thus, one can hypothesise that the proliferation of cerebral meningiomas may be under dopaminergic control and that dopamine agonists such cabergoline may have a potential role in the medical treatment of patients with meningiomas.
Authors:
Camil Castelo-Branco; María José Martinez; Juan Balasch
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-05-26
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  27     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-14     Completed Date:  2011-05-04     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  134-7     Citation Subset:  IM    
Affiliation:
Institut Clinic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine-University of Barcelona, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. castelobranco@ub.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Disease Progression
Dopamine Agonists / adverse effects
Ergolines / adverse effects*
Female
Humans
Meningeal Neoplasms / chemically induced*,  diagnosis
Meningioma / chemically induced*,  diagnosis
Neoplasms, Hormone-Dependent / chemically induced*
Chemical
Reg. No./Substance:
0/Dopamine Agonists; 0/Ergolines; LL60K9J05T/cabergoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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