| Further analysis of lethal factors in cycloheximide-treated mice given low doses of bacterial lipopolysaccharide. | |
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MedLine Citation:
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PMID: 2715398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endotoxin challenge (0.2 micrograms per mouse) 6 h after a standard dose of cycloheximide was compared with the previously-reported effects of simultaneous injection of cycloheximide and endotoxin. With the submicrogram dose of endotoxin given 6 h after cycloheximide, fatalities occurred without evidence of thrombogenic bilateral renal cortical necrosis which characterized mice dying after the two agents were given together. Anticoagulation with heparin or with ancrod is life-saving, indicating that cycloheximide-treated mice were fatally susceptible to fibrinogen-to-fibrin conversion, and that, in contrast to the situation where cycloheximide and endotoxin are given simultaneously, there was no essential demand for supplementary glycocorticosteroid. A dose of 5.0 micrograms of endotoxin given 6 h after cycloheximide was fatal; again no renal cortical necrosis occurred, but both ancrod and hydrocortisone were essential to ensure survival. |
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Authors:
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E W Parry |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of comparative pathology Volume: 100 ISSN: 0021-9975 ISO Abbreviation: J. Comp. Pathol. Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-06-19 Completed Date: 1989-06-19 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0102444 Medline TA: J Comp Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 155-60 Citation Subset: IM |
Affiliation:
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Department of Human Anatomy and Cell Biology, The University, Liverpool, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ancrod
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therapeutic use Animals Cycloheximide / pharmacology* Endotoxins / toxicity Heparin / therapeutic use Hydrocortisone / therapeutic use Lipopolysaccharides / toxicity* Male Mice Mice, Inbred CBA Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 0/Lipopolysaccharides; 50-23-7/Hydrocortisone; 66-81-9/Cycloheximide; 9005-49-6/Heparin; EC 3.4.21.-/Ancrod |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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