Document Detail

Further Investigations into the Speed of Cerebral Swelling Following Blunt Cranial Trauma*
MedLine Citation:
PMID:  22372694     Owner:  NLM     Status:  Publisher    
  An anesthetized sheep model of traumatic brain injury (TBI) has been developed to assess early changes in intracranial pressure (ICP) following closed head injury. Immediately after TBI, a transient (<10 min) hypertensive response occurred, followed by significant and prolonged systemic hypotension. ICP demonstrated a biphasic response, being seven times baseline values of 8 ± 2 mm Hg 10 min after injury, decreasing to 25 ± 2 mm Hg by 30 min, and then increasing to values exceeding 30 mm Hg by 4 h postinjury. ICP was always significantly higher than baseline values, which combined with hypotension, reduced cerebral perfusion pressure to less than 60% of normal. This early and sustained increase in ICP after craniocerebral trauma acutely alters cerebral perfusion pressure and brain oxygenation and provides a potential pathophysiological explanation for immediate clinical manifestations in humans following significant TBI.
Roger W Byard; Levon Gabrielian; Stephen C Helps; Emma Thornton; Robert Vink
Related Documents :
7558224 - Atrial natriuretic peptide in chronically hypertensive dogs.
2954474 - Natriuretic response to homologous heart extract in aglomerular toadfish.
2937724 - Cardiovascular effects of atrial natriuretic factor in anesthetized and conscious dogs.
2522284 - Mechanism for decrease in cardiac output with atrial natriuretic peptide in dogs.
518454 - Technique for simulating g-induced tunnel vision.
1388314 - Atrial natriuretic peptide attenuates pressor but enhances natriuretic responses to ang...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-28
Journal Detail:
Title:  Journal of forensic sciences     Volume:  -     ISSN:  1556-4029     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 American Academy of Forensic Sciences.
Adelaide Centre for Neuroscience Research, School of Medical Sciences, The University of Adelaide, Frome Road, Adelaide, SA 5005, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Enantioselective synthesis of (-)-basiliskamide A.
Next Document:  Youth with disabilities' perspectives of the environment and participation: a qualitative meta-synth...