Document Detail


Furosemide pharmacokinetics and pharmacodynamics in health and disease--an update.
MedLine Citation:
PMID:  2654356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The literature on furosemide pharmacokinetics and pharmacodynamics is critically reviewed, concentrating on those papers published subsequent to the 1979 reviews of this topic. Intravenous and oral data are presented for healthy volunteers and for patients with various disease states. It is the latter populations about which the majority of the studies have been published since 1979. Inter- and intraindividual variations in bioavailability are discussed, as are data on the metabolism of furosemide to its glucuronide conjugate. Published studies examining the relationship between furosemide pharmacodynamics and pharmacokinetics are also evaluated. The literature is reviewed through June 1988.
Authors:
M Hammarlund-Udenaes; L Z Benet
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of pharmacokinetics and biopharmaceutics     Volume:  17     ISSN:  0090-466X     ISO Abbreviation:  J Pharmacokinet Biopharm     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-06-22     Completed Date:  1989-06-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0357115     Medline TA:  J Pharmacokinet Biopharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-46     Citation Subset:  IM    
Affiliation:
Department of Pharmacy, School of Pharmacy, University of California, San Francisco 94143-0446.
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MeSH Terms
Descriptor/Qualifier:
Disease / metabolism
Furosemide / pharmacokinetics*,  pharmacology
Health
Humans
Grant Support
ID/Acronym/Agency:
GM26691/GM/NIGMS NIH HHS; GM36633/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
54-31-9/Furosemide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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