Document Detail

Fungal siderophores function as protective agents of LDL oxidation and are promising anti-atherosclerotic metabolites in functional food.
MedLine Citation:
PMID:  18646004     Owner:  NLM     Status:  MEDLINE    
Iron-mediated oxidation of low-density lipoprotein has been implicated in the pathogenesis of vascular disorders such as atherosclerosis. The present investigations were performed to test whether hydrophobic fungal siderophores - hexadentate trihydroxamates desferricoprogen, desferrichrome, desferrirubin, and desferrichrysin - might suppress heme-catalyzed LDL oxidation and the toxic effects of heme-treated LDL on vascular endothelium. Indeed, two of these - desferricoprogen and desferrichrome - markedly increased the resistance of LDL to heme-catalyzed oxidation. In similar dose-response fashion, these siderophores also inhibited the generation of LDL products cytotoxic to human vascular endothelium. When iron-free fungal siderophores were added to LDL/heme oxidation reactions, the product failed to induce heme oxygenase-1, a surrogate marker for the noncytocidal effects of oxidized LDL (not in the case of desferrichrysin). Desferricoprogen also hindered the iron-mediated peroxidation of lipids from human atherosclerotic soft plaques in vitro, and was taken up in the gastrointestinal tract of rat. The absorbed siderophore was accumulated in the liver and was secreted in its iron-complexed form in the feces and urine. The consumption of mold-ripened food products such as aged cheeses and the introduction of functional foods and food additives rich in fungal iron chelators in diets may lower the risk of cardiovascular diseases.
István Pócsi; Viktória Jeney; Pál Kertai; Imre Pócsi; Tamás Emri; Gyöngyi Gyémánt; László Fésüs; József Balla; György Balla
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  52     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1434-47     Citation Subset:  IM    
Department of Microbial Biotechnology and Cell Biology, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary.
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MeSH Terms
Atherosclerosis / prevention & control*
Diketopiperazines / pharmacokinetics,  pharmacology*
Dose-Response Relationship, Drug
Heme Oxygenase-1 / genetics
Hydroxamic Acids / pharmacokinetics,  pharmacology*
Iron Chelating Agents / pharmacology
Lipid Peroxidation / drug effects
Lipoproteins, LDL / metabolism*
Liver / metabolism
Protective Agents / pharmacology
Siderophores / pharmacology*
Reg. No./Substance:
0/Diketopiperazines; 0/Hydroxamic Acids; 0/Iron Chelating Agents; 0/Lipoproteins, LDL; 0/Protective Agents; 0/Siderophores; 0/oxidized low density lipoprotein; 100811-54-9/desferricoprogen; 31418-71-0/coprogen; EC Oxygenase-1

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