| Fungal peritonitis in patients on peritoneal dialysis. | |
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MedLine Citation:
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PMID: 8080003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fungal peritonitis (FP) is a serious complication of peritoneal dialysis, both in terms of morbidity and mortality. Available data on the effectiveness of fluconazole in eradicating FP without catheter removal are still controversial. We reviewed 20 FP cases that occurred among 325 patients who underwent peritoneal dialysis in our center between January 1984 and January 1992, in order to establish whether a profile of patients at risk of developing FP could be identified and to evaluate the effectiveness of fluconazole in treating FP (7 cases). Age, sex, a particular cause of end-stage renal disease, and the presence of diabetes did not correlate significantly with the development of FP. The risk of FP increased in patients on immunosuppressive treatment. Sixteen of our 20 patients had bacterial peritonitis during the month before they developed FP. Nineteen were treated with antibiotics. Neither the type of bacterial organism isolated during the bacterial peritonitis preceding FP nor modality and duration of antibiotic treatment correlated significantly with the development of FP. Patients who subsequently developed FP were more frequently treated with antibiotics while in hospital (p < 0.001). Candida species accounted for 15 of our 20 FP cases (75%), with Candida albicans being by far the most common isolate. Treatment strategies varied among the 20 patients. The combination of intravenous or intraperitoneal administration of 5-fluorocytosine and oral administration of fluconazole was used in 7 cases: only 1 patient was cured without catheter removal, 1 patient died within the first 4 days of treatment, removal of peritoneal catheter was necessary in the other 5 patients.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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C Michel; L Courdavault; R al Khayat; B Viron; P Roux; F Mignon |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of nephrology Volume: 14 ISSN: 0250-8095 ISO Abbreviation: Am. J. Nephrol. Publication Date: 1994 |
Date Detail:
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Created Date: 1994-10-04 Completed Date: 1994-10-04 Revised Date: 2007-02-14 |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 113-20 Citation Subset: IM |
Affiliation:
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Service de Néphrologie, Hôpital Tenon, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anti-Bacterial Agents / therapeutic use* Antifungal Agents / therapeutic use* Candidiasis* Drug Administration Routes Drug Therapy, Combination Female Fluconazole / therapeutic use Flucytosine / therapeutic use Humans Ketoconazole / therapeutic use Kidney Failure, Chronic / etiology, immunology, therapy Length of Stay Male Middle Aged Mycoses* Peritoneal Dialysis Peritonitis / drug therapy*, immunology, microbiology Risk Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Antifungal Agents; 2022-85-7/Flucytosine; 65277-42-1/Ketoconazole; 86386-73-4/Fluconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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