Document Detail

Fungal nucleic acids as interferon inducers.
MedLine Citation:
PMID:  94746     Owner:  NLM     Status:  MEDLINE    
Nucleic acids isolated from the fungi Aspergillus niger x11, Piptoporus betulinus and Ganoderma applanatum reduced the number of vaccinia virus plaques in chick embryo fibroblast (CEF) tissue culture and when administered intravenously to white mice protected them against lethal infection with tick borne encephalitis virus strain K5 (TBE). In CEF tissue culture the nucleic acids of the studied fungi were found to induce small but detectable amounts of a substance with the character of interferon. In vivo only ribonucleic acid from G. applanatum induced a substance showing interferon properties in the spleen of mice.
M Kandefer-Szerszeń; Z Kawecki; M Guz
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Acta microbiologica Polonica     Volume:  28     ISSN:  0137-1320     ISO Abbreviation:  Acta Microbiol. Pol.     Publication Date:  1979  
Date Detail:
Created Date:  1980-07-22     Completed Date:  1980-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7610362     Medline TA:  Acta Microbiol Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  277-91     Citation Subset:  IM    
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MeSH Terms
Aspergillus niger
Chick Embryo
Culture Techniques / methods
Encephalitis, Tick-Borne / prevention & control
Fibroblasts / microbiology
Interferon Inducers / therapeutic use*
Nucleic Acids / therapeutic use*
Plaque Assay
Tissue Extracts / therapeutic use*
Vaccinia virus / drug effects
Reg. No./Substance:
0/Interferon Inducers; 0/Nucleic Acids; 0/Tissue Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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