Document Detail


Fungal evo-devo: organelles and multicellular complexity.
MedLine Citation:
PMID:  20888233     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peroxisome-derived Woronin bodies of the Ascomycota phyla, and the endoplasmic reticulum (ER)-derived septal pore cap (SPC) of the Basidiomycota, are both fungal organelles that prevent cytoplasmic bleeding when multicellular hyphal filaments are wounded. Analysis of Woronin body constituent proteins suggests that these organelles evolved in part through gene duplication and co-opting of non-essential genes for new functions, indicating that new organelles can arise through typical evolutionary mechanisms. Interestingly, clades possessing the Woronin body and SPC also produce the largest and most complex multicellular fungal reproductive structures. Certain Woronin body and SPC mutants have defects in growth and development, suggesting functions beyond cellular wound healing. I argue that studying these specialized systems will help to reveal the basis for fungal diversity and provide general principles for co-evolution of organelles and multicellular complexity.
Authors:
Gregory Jedd
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-29
Journal Detail:
Title:  Trends in cell biology     Volume:  21     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-03     Completed Date:  2011-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  12-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Temasek Life Sciences Laboratory and Department of Biological Sciences, The National University of Singapore, Singapore 117604. gregory@tll.org.sg
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MeSH Terms
Descriptor/Qualifier:
Ascomycota / cytology,  genetics
Basidiomycota / cytology,  genetics
Cytoplasm / metabolism
Fungi / cytology*,  genetics*,  metabolism
Organelles / genetics*,  metabolism

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