| Fungal chitin-glucan from Aspergillus niger efficiently reduces aortic fatty streak accumulation in the high-fat fed hamster, an animal model of nutritionally induced atherosclerosis. | |
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MedLine Citation:
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PMID: 19154104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of chitin-glucan (CG) on early atherosclerosis, cardiac production of superoxide anion, and hepatic antioxidant enzymes were studied in an animal model of atherosclerosis. Three groups of 12 hamsters were fed an atherogenic diet for 12 weeks. They received by gavage either water (control group) or CG in water at a dose of 21.4 mg/kg BW x d-1 of chitin-glucan (CG ld) or 42.8 mg/kg BW x d-1 (GG hd). CG did not affect plasma cholesterol but lowered triglycerides. It also strongly reduced the area of aortic fatty streak deposition by 87-97%, cardiac production of superoxide anion by 25% and liver MDA by 77-85%, and enhanced liver superoxide dismutase activity by 7-45% and glutathionne peroxidase activity by 38-120%. These findings support the view that chronic consumption of chitin-glucan has potential beneficial effects with respect to the development of atherosclerosis. The underlying mechanism is related mainly to improving the antioxidant status. |
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Authors:
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Arlet Berecochea-Lopez; Kelly Decordé; Emilie Ventura; Marlène Godard; Aurélie Bornet; Pierre-Louis Teissèdre; Jean-Paul Cristol; Jean-Max Rouanet |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 57 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-05 Completed Date: 2009-03-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 1093-8 Citation Subset: IM |
Affiliation:
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Université Montpellier 2, Montpellier cedex 5, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / pathology* Aspergillus niger / chemistry* Atherosclerosis / etiology, pathology, prevention & control* Chitin / administration & dosage* Cricetinae Diet Diet, Atherogenic* Dietary Fats / administration & dosage Disease Models, Animal Glucans / administration & dosage* Male Mesocricetus |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Glucans; 1398-61-4/Chitin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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