Document Detail

Fungal cerebral abscess in a diabetic patient successfully treated with surgery followed by prolonged antifungal therapy.
MedLine Citation:
PMID:  20189857     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intracranial fungal masses are uncommon diseases, but their incidence is increasing, most often due to the prolonged survival of patients with different immunodeficiencies. The management of patients with intracranial fungal masses included stereotactic biopsy for diagnosis, partial or radical surgery excision and prolonged antifungal therapy.
AIMS: We report the case of a 51-year-old diabetic man with a history of psoas abscess due to Candida albicans 1 year before the onset of neurological symptoms, including headache and generalized tonoclonic seizures.
METHODS: Magnetic resonance imaging showed a single lesion located in the right parietal lobe with mass effect, surrounding edema and enhancement after injection of gadolinium. The material was purulent.
RESULTS: Direct microscopic examination showed hyaline, branched and septate hyphae compatible with fungal elements.
CONCLUSIONS: Fungal infections, especially due to Candida species, should be considered in diabetic patients with parenchymal brain abscesses. Radical excision followed by prolonged antifungal therapy based on fluconazole or amphotericin B is necessary to improve the prognosis of this type of patients.
Claudio Yampolsky; Marcelo Corti; Ricardo Negroni
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-03-01
Journal Detail:
Title:  Revista iberoamericana de micología     Volume:  27     ISSN:  1130-1406     ISO Abbreviation:  Rev Iberoam Micol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-06-22     Revised Date:  2012-05-01    
Medline Journal Info:
Nlm Unique ID:  9425531     Medline TA:  Rev Iberoam Micol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  6-9     Citation Subset:  IM    
Copyright Information:
2009 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.
Department of Infectious Diseases, F.J. Muñiz Hospital, Buenos Aires, Argentina.
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MeSH Terms
Amphotericin B / administration & dosage,  therapeutic use*
Antifungal Agents / therapeutic use*
Brain Abscess / complications,  drug therapy,  surgery*
Candida albicans / isolation & purification
Candidiasis / complications,  drug therapy,  surgery*
Combined Modality Therapy
Deoxycholic Acid / administration & dosage,  therapeutic use*
Diabetes Mellitus, Type 2 / complications*
Drug Combinations
Drug Therapy, Combination
Fluconazole / administration & dosage,  therapeutic use*
Hyphae / isolation & purification
Magnetic Resonance Imaging
Mannitol / therapeutic use
Middle Aged
Parietal Lobe / microbiology*
Psoas Abscess / complications,  microbiology
Reg. No./Substance:
0/Antifungal Agents; 0/Drug Combinations; 1397-89-3/Amphotericin B; 69-65-8/Mannitol; 83-44-3/Deoxycholic Acid; 86386-73-4/Fluconazole; 87687-70-5/amphotericin B, deoxycholate drug combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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