Document Detail

Fundic gland polyps (Elster's cysts) of the gastric mucosa. A marker for colorectal epithelial neoplasia?
MedLine Citation:
PMID:  12530575     Owner:  NLM     Status:  MEDLINE    
The results of several retrospective studies allow us to conclude that the detection of fundic gland polyps (Elster's cysts) is associated with an increased incidence of colorectal tumors. In this survey, we present the results of a prospective study investigating such a possible relationship. A total of 144 patients were investigated, of whom 80 had fundic gland polyps of the gastric corpus mucosa. Sixty-four of these patients underwent a colonoscopy, whereas the other 64 patients belonged to a sex- and age-matched control group with no fundic gland polyps. In the group with known fundic gland polyps, colorectal neoplasias were found in 29 (45.3%) patients. Eight of these patients had (12.5%) adenocarcinomas, 3 (4.7%) had high-grade intraepithelial neoplasia, and 18 (28.1%) had tubular adenomas. In one patient, a synchronous carcinoma of the rectum and the colon was detected. In comparison, 6 patients of the control group (9.3%) developed tubular adenomas and 9 (14.1%) had hyperplastic polyps of the colonic and rectal mucosa. Our results suggest that it is necessary to conduct a careful diagnostic work-up of the colon in patients with gastric fundic gland polyps.
A Jung; M Vieth; O Maier; M Stolte
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  198     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2002  
Date Detail:
Created Date:  2003-01-17     Completed Date:  2003-06-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  731-4     Citation Subset:  IM    
Praxis für Gastroenterologie, Augsburg, Germany.
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MeSH Terms
Colorectal Neoplasms / complications*
Gastric Fundus / pathology*
Gastric Mucosa / pathology
Middle Aged
Polyps / complications*,  pathology
Prospective Studies
Tumor Markers, Biological / metabolism*
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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