| Fundic argyrophil cell hyperplasia in atrophic gastritis: a search for a sensitive diagnostic method. | |
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MedLine Citation:
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PMID: 7688175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypergastrinemia induces argyrophil cell hyperplasia in oxyntic mucosa (FACH) in patients with non-antral atrophic gastritis, with or without pernicious anemia. This proliferation favours the development of carcinoid tumours. In order to determine the most usual appropriate method to document FACH, we have studied 29 consecutive fundic biopsies from 26 patients with fundic chronic gastritis. The study encompassed gastrinemia levels, standard histology permitting the classification of chronic gastritis, demonstration of FACH by Grimelius stain, immunohistochemical studies using NSE, chromogranin A and by electron microscopy. The FACH was classified for each stain as slight, moderate or severe. The study displayed a relationship between the grade of gastritis and the density of argyrophil endocrine cells in oxyntic mucosa assessed by Grimelius stain (p < 0.0001) and chromogranin A (P < 0.01). There was also a relationship between the serum gastrin level and the density of argyrophil endocrine cells detected by these two stains (p < 0.001). A highly significant correlation was observed between Grimelius stain and chromogranin A (p < 0.0001). On the other hand, no significant correlation was noted with either NSE or electron microscopy. We conclude that Grimelius stain and immunohistochemical studies against chromogranin A were the best methods for the demonstration of FACH in atrophic gastritis. One of these two techniques is sufficient in current practice for defining the patients at risk for subsequent surveillance. |
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Authors:
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J Belaiche; J Delwaide; M Vivario; P Gast; E Louis; J Boniver |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta gastro-enterologica Belgica Volume: 56 ISSN: 0001-5644 ISO Abbreviation: Acta Gastroenterol. Belg. Publication Date: 1993 Jan-Feb |
Date Detail:
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Created Date: 1993-09-02 Completed Date: 1993-09-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0414075 Medline TA: Acta Gastroenterol Belg Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 11-7 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, University of Liège, CHU Sart Tilman, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Pernicious
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complications Biopsy Enterochromaffin Cells / pathology* Gastric Mucosa / pathology Gastrins / blood Gastritis, Atrophic / blood, complications, pathology* Histological Techniques Humans Hyperplasia Staining and Labeling |
| Chemical | |
Reg. No./Substance:
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0/Gastrins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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