| Fundamentals of pharmacology and applications in pharmacogenetics. | |
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MedLine Citation:
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PMID: 19059057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article provides an introduction to the fundamental principles of pharmacokinetics (PK) and pharmacodynamics (PD) as they apply to understanding the application of pharmacogenetics (PGx) in a clinical setting. PGx establishes connections between the disciplines of pharmacology and genetics. As such, one functional component of PGx involves establishing relationships between phenotypes and genotypes with respect to predicting the response of medications in individual patients. The article begins by describing each of the concepts, followed by discussing the clinical utility of PGx and pharmacodynamics in a laboratory medicine setting; it then makes a link with the evolving field of PGx from the perspective of clinical laboratory medicine. Laboratory medicine serves as a catalyst for transitioning PGx into clinical settings, and as such, the article concludes by describing the future role of clinical laboratories in the application of PGx to patient care. |
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Authors:
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Mohammad Al-Ghoul; Roland Valdes |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinics in laboratory medicine Volume: 28 ISSN: 1557-9832 ISO Abbreviation: Clin. Lab. Med. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-08 Completed Date: 2009-03-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100174 Medline TA: Clin Lab Med Country: United States |
Other Details:
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Languages: eng Pagination: 485-97 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, University of Louisville, School of Medicine, Louisville, KY 40292, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Laboratory Techniques Cytochrome P-450 Enzyme System / physiology Humans Pharmaceutical Preparations / administration & dosage Pharmacogenetics / methods, trends* Pharmacokinetics Polymorphism, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations; 9035-51-2/Cytochrome P-450 Enzyme System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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