Document Detail

Fundamentals of inertial focusing in microchannels.
MedLine Citation:
PMID:  23353899     Owner:  NLM     Status:  Publisher    
Inertial microfluidics has been attracting considerable interest in recent years due to immensely promising applications in cell biology. Despite the intense attention, the primary focus has been on development of inertial microfluidic devices with less emphasis paid to elucidation of the inertial focusing mechanics. The incomplete understanding, and sometimes confusing experimental results that indicate a different number of focusing positions in square or rectangular microchannels under similar flow conditions, have led to poor guidelines and difficulties in design of inertial microfluidic systems. In this work, we describe and experimentally validate a two-stage model inertial focusing in microchannels. Our analysis and experimental results show that not only the well-accepted shear-induced and wall-induced lift forces act on particles within flow causing equilibration near microchannel sidewalls, but the rotation-induced lift force influences the position of these equilibria. In addition, for the first time, we experimentally measure lift coefficients, which previously could only be obtained from numerical simulations. More importantly, insights offered by our two-stage model of inertial focusing are broadly applicable to cross-sectional geometries beyond rectangular. With elucidation of the equilibration mechanism, we envision better guidelines for the inertial microfluidics community, ultimately leading to improved performance and broader acceptance of the inertial microfluidic devices in a wide range of applications, from filtration to cell separations.
Jian Zhou; Ian Papautsky
Related Documents :
24041579 - The acceleration dependent validity and reliability of 10hz gps.
24145429 - Pneumatic oscillator circuits for timing and control of integrated microfluidics.
23722749 - Low-threshold raman laser from an on-chip, high-q, polymer-coated microcavity.
23805879 - Deep-subwavelength plasmonic nanoresonators exploiting extreme coupling.
24245999 - Materials for microfluidic chip fabrication.
23041869 - Omnidirectional luminescence enhancement of fluorescent sic via pseudoperiodic antirefl...
19045419 - Nonequilibrium thermodynamics of interfaces using classical density functional theory.
23509379 - Stabilizing and destabilizing perturbations of -symmetric indefinitely damped systems.
24514349 - Efficient 1535 nm light emission from an all-si-based optical micro-cavity containing e...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  Lab on a chip     Volume:  -     ISSN:  1473-0189     ISO Abbreviation:  Lab Chip     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
BioMicroSystems Lab, School of Electronic and Computing Systems, University of Cincinnati, Cincinnati, OH 45221.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Stem-bark of Terminalia arjuna attenuates Human monocytic (THP-1) and aortic endothelial cell activa...
Next Document:  Voltammetric discrimination of skatole and indole at disposable screen printed electrodes.