Document Detail


Fundamental concepts of the angiogenic process.
MedLine Citation:
PMID:  14601638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The process of angiogenesis encompasses the growth and regression of capillary blood vessels. Angiogenesis is finely regulated at the molecular and genetic levels, not unlike other physiologic processes such as coagulation, glucose metabolism, and blood pressure. During the development of the field of angiogenesis research over the past three decades, fundamental concepts have been introduced along the way in an attempt where possible, to unify new data from a variety of different laboratories. I have assembled here the major concepts which underlie the angiogenic process as we currently understand it. Many of these are now taken for granted, but this was not always the case, and I have tried to show how they were developed. My goal is to provide a conceptual framework for those basic scientists or clinicians who may enter this rapidly expanding field. Each concept discussed here is accompanied by a few key references as a guide to the pertinent literature.
Authors:
Judah Folkman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current molecular medicine     Volume:  3     ISSN:  1566-5240     ISO Abbreviation:  Curr. Mol. Med.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-06     Completed Date:  2003-12-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101093076     Medline TA:  Curr Mol Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  643-51     Citation Subset:  IM    
Affiliation:
Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. judah.folkman@tch.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Aneuploidy
Angiogenesis Inhibitors / pharmacology
Angiogenic Proteins / metabolism
Animals
Extracellular Matrix / metabolism
Humans
Mice
Neoplasms* / blood supply,  drug therapy
Neovascularization, Pathologic* / drug therapy
Chemical
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Angiogenic Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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