| Fundamental concepts of the angiogenic process. | |
| | |
MedLine Citation:
|
PMID: 14601638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The process of angiogenesis encompasses the growth and regression of capillary blood vessels. Angiogenesis is finely regulated at the molecular and genetic levels, not unlike other physiologic processes such as coagulation, glucose metabolism, and blood pressure. During the development of the field of angiogenesis research over the past three decades, fundamental concepts have been introduced along the way in an attempt where possible, to unify new data from a variety of different laboratories. I have assembled here the major concepts which underlie the angiogenic process as we currently understand it. Many of these are now taken for granted, but this was not always the case, and I have tried to show how they were developed. My goal is to provide a conceptual framework for those basic scientists or clinicians who may enter this rapidly expanding field. Each concept discussed here is accompanied by a few key references as a guide to the pertinent literature. |
| | |
Authors:
|
Judah Folkman |
Related Documents
:
|
15851858 - The 2003 national pediatric pressure ulcer and skin breakdown prevalence survey: a mult... 11669568 - Reduced incidence of pressure ulcers in patients with hip fractures: a 2-year follow-up... 3565218 - Pressure ulcers. 21033268 - Facility dramatically reduces pressure ulcers. 22620708 - Effects of unilateral arytenoid lateralization technique and suture tension on airway p... 17814858 - Isolation of a deep-sea barophilic bacterium and some of its growth characteristics. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current molecular medicine Volume: 3 ISSN: 1566-5240 ISO Abbreviation: Curr. Mol. Med. Publication Date: 2003 Nov |
Date Detail:
|
Created Date: 2003-11-06 Completed Date: 2003-12-10 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 101093076 Medline TA: Curr Mol Med Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 643-51 Citation Subset: IM |
Affiliation:
|
Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. judah.folkman@tch.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aneuploidy Angiogenesis Inhibitors / pharmacology Angiogenic Proteins / metabolism Animals Extracellular Matrix / metabolism Humans Mice Neoplasms* / blood supply, drug therapy Neovascularization, Pathologic* / drug therapy |
| Chemical | |
Reg. No./Substance:
|
0/Angiogenesis Inhibitors; 0/Angiogenic Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of apoptosis in tumor progression and metastasis.
Next Document: Role of maspin in tumor metastasis and angiogenesis.