| Fundamental aspects of neural-immune signaling. | |
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MedLine Citation:
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PMID: 7901868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Noradrenergic and peptidergic nerve fibers abundantly innervate the parenchyma of both primary (bone marrow) and secondary (spleen, lymph nodes) lymphoid organs. Nerve fibers distribute within the parenchyma of these organs, as well as along smooth muscle compartments. Both noradrenaline and peptides such as substance P have been shown to fulfill the basic criteria for neurotransmission with lymphocytes, macrophages, and other immunocytes as targets. Denervation or pharmacological manipulation of these neurotransmitters can profoundly alter immunological reactivity at the individual cellular level, at the level of complex multicellular interactions (such as antibody response), and at the level of host response to a disease-producing challenge. The characteristic and mechanisms of bidirectional neural-immune signaling may provide a novel approach to immunologically-mediated disease, both pharmacologically and behaviorally. |
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Authors:
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D L Felten; S Y Felten; D L Bellinger; K S Madden |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Psychotherapy and psychosomatics Volume: 60 ISSN: 0033-3190 ISO Abbreviation: Psychother Psychosom Publication Date: 1993 |
Date Detail:
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Created Date: 1993-12-22 Completed Date: 1993-12-22 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0024046 Medline TA: Psychother Psychosom Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 46-56 Citation Subset: IM |
Affiliation:
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Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, NY 14642. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Immune System / physiology* Lymphocytes / immunology, physiology Male Neural Conduction / immunology* Neuroimmunomodulation Neuropeptides / immunology, physiology Neurotransmitter Agents / immunology, physiology Norepinephrine / immunology, physiology Protein Sorting Signals / immunology, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptides; 0/Neurotransmitter Agents; 0/Protein Sorting Signals; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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