| Fundamental aspects of the impact of glucocorticoids on the (immature) brain. | |
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MedLine Citation:
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PMID: 19073374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this review, studies on the role of glucocorticoids during brain development are recapitulated with reference to their immediate effects and long-term impact on central functions. Traditionally, this research has focused on detrimental consequences of stress and exogenous glucocorticoid exposure but far less on the ability to develop resilience to stress despite exposure to early adversity. Recent findings suggest that the impact of early life conditions turns out as either harmful or protective depending on later environmental context. To explain this, the concept of 'predictive adaptive response' was introduced, implying that early-life conditions may prepare for life ahead through glucocorticoid programming and phenotypic plasticity with the goal to 'match' future environmental demands. This concept has led to the hypothesis that a 'mismatch' between early and later life conditions can enhance vulnerability to disease. |
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Authors:
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Danielle L Champagne; E Ronald de Kloet; Marian Joëls |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-14 |
Journal Detail:
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Title: Seminars in fetal & neonatal medicine Volume: 14 ISSN: 1744-165X ISO Abbreviation: - Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-03-30 Completed Date: 2009-06-18 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 101240003 Medline TA: Semin Fetal Neonatal Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 136-42 Citation Subset: IM |
Affiliation:
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Department of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research/Leiden University Medical Center, Gorlaeus Laboratory, Leiden, The Netherlands. d.champagne@chem.leidenuniv.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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physiology* Animals Brain / growth & development* Child Development / physiology Environment Feedback, Physiological Humans Hypothalamo-Hypophyseal System / physiology Infant Models, Animal Pituitary-Adrenal System / physiology Rats Receptors, Glucocorticoid / physiology Receptors, Mineralocorticoid / physiology Stress, Physiological / physiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Receptors, Glucocorticoid; 0/Receptors, Mineralocorticoid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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