Document Detail

Functions of intrinsic defense against anaerobic bacteria in healthy probands and patients with chronic-septic granulomatosis
MedLine Citation:
PMID:  3573679     Owner:  NLM     Status:  MEDLINE    
Different strains of Bacteroides fragilis exhibit great differences in sensitivity towards serum from healthy volunteers. In the presence of 10% autologous serum, neutrophilic granulocytes and monocytes (macrophages) caused significant killing of B. fragilis. The measured phagocytic and killing activity of the cells is comparable to their activity against aerobic bacteria (S. aureus). In four patients with chronic granulomatous disease of childhood, phagocytosis was normal but killing of B. fragilis and S. aureus in granulocytes or monocytes (macrophages) was appreciably lowered. This malfunction of the cells was accompanied by a disturbance in oxidative metabolism and inadequate iodination after phagocytosis of B. fragilis. The results suggest that granulocytes and monocytes play an important role in host defense against endogenous infections with anaerobes.
A Wildfeuer; R Dopfer; D Niethammer; J Galle; H Laufen; O Haferkamp; E Vanek
Publication Detail:
Type:  Case Reports; English Abstract; Journal Article    
Journal Detail:
Title:  Klinische Wochenschrift     Volume:  65     ISSN:  0023-2173     ISO Abbreviation:  Klin. Wochenschr.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-05-28     Completed Date:  1987-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985205R     Medline TA:  Klin Wochenschr     Country:  GERMANY, WEST    
Other Details:
Languages:  ger     Pagination:  113-20     Citation Subset:  IM    
Vernacular Title:
Funktionen der körpereigenen Abwehr gegen Anaerobier bei Gesunden und Patienten mit chronisch-septischer Granulomatose.
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MeSH Terms
Abscess / immunology
Bacteroides Infections / immunology*
Bacteroides fragilis / immunology
Granulocytes / immunology
Granulomatous Disease, Chronic / immunology*
Immune Tolerance
Immunity, Cellular
Macrophages / immunology
Staphylococcus aureus / immunology

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