Document Detail

Functions and cellular compartmentation of the thioredoxin and glutathione pathways in yeast.
MedLine Citation:
PMID:  23198979     Owner:  NLM     Status:  MEDLINE    
SIGNIFICANCE: The thioredoxin (TRX) and glutathione (GSH) pathways are universally conserved thiol-reductase systems that drive an array of cellular functions involving reversible disulfide formation. Here we consider these pathways in Saccharomyces cerevisiae, focusing on their cell compartment-specific functions, as well as the mechanisms that explain extreme differences of redox states between compartments.
RECENT ADVANCES: Recent work leads to a model in which the yeast TRX and GSH pathways are not redundant, in contrast to Escherichia coli. The cytosol possesses full sets of both pathways, of which the TRX pathway is dominant, while the GSH pathway acts as back up of the former. The mitochondrial matrix also possesses entire sets of both pathways, in which the GSH pathway has major role in redox control. In both compartments, GSH has also nonredox functions in iron metabolism, essential for viability. The endoplasmic reticulum (ER) and mitochondrial intermembrane space (IMS) are sites of intense thiol oxidation, but except GSH lack thiol-reductase pathways.
CRITICAL ISSUES: What are the thiol-redox links between compartments? Mitochondria are totally independent, and insulated from the other compartments. The cytosol is also totally independent, but also provides reducing power to the ER and IMS, possibly by ways of reduced and oxidized GSH entering and exiting these compartments.
FUTURE DIRECTIONS: Identifying the mechanisms regulating fluxes of GSH and oxidized glutathione between cytosol and ER, IMS, and possibly also peroxisomes, vacuole is needed to establish the proposed model of eukaryotic thiol-redox homeostasis, which should facilitate exploration of this system in mammals and plants.
Michel B Toledano; Agnès Delaunay-Moisan; Caryn E Outten; Aeid Igbaria
Related Documents :
23416979 - Senescence and aging: the critical roles of p53.
24669209 - Redox regulation and the autistic spectrum: role of tryptophan catabolites, immuno-infl...
23889949 - Novel pharmacologic treatment attenuates septic shock and improves long-term survival.
15163549 - Apoptotic injury in cultured human hepatocytes induced by hmg-coa reductase inhibitors.
24974289 - Using rnai screening technologies to interrogate the extrinsic apoptosis pathway.
24138989 - Construction of the influenza a virus infection-induced cell-specific inflammatory regu...
20814419 - Human-iapp disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective ...
1524839 - Comparative ability of human monocytes and macrophages to control the intracellular gro...
7039439 - Alveolar macrophage kinetics and function after interruption of canine marrow function.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-02-05
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  18     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-01     Completed Date:  2013-09-13     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1699-711     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Glutathione / metabolism*
Intracellular Space / metabolism
Metabolic Networks and Pathways*
Sulfhydryl Compounds / metabolism
Thioredoxins / metabolism*
Yeasts / metabolism*
Grant Support
Reg. No./Substance:
0/Sulfhydryl Compounds; 52500-60-4/Thioredoxins; GAN16C9B8O/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Association between hypoglycemia and inpatient mortality and length of hospital stay in hospitalized...
Next Document:  Competing Weak Localization and Weak Antilocalization in Ultrathin Topological Insulators.