Document Detail


Functions and biosynthesis of plasmalogens in health and disease.
MedLine Citation:
PMID:  15164770     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasmalogens (1-O-alk-1'-enyl-2-acyl glycerophospholipids) constitute a special class of phospholipids characterized by the presence of a vinyl-ether bond at the sn-1 position. Although long considered as biological peculiarities, interest in this group of phospholipids has grown in recent years, thanks to the realization that plasmalogens are involved in different human diseases. In this review, we summarize the current state of knowledge with respect to the enzymatic synthesis of plasmalogens, the characteristic topology of the enzymes involved and the biological roles that have been assigned to plasmalogens.
Authors:
Pedro Brites; Hans R Waterham; Ronald J A Wanders
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1636     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-05-28     Completed Date:  2004-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  219-31     Citation Subset:  IM    
Affiliation:
Department of Clinical Chemistry, Academic Medical Center, Lab Genetic Metabolic Diseases, F0-224, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Humans
Hydrolysis
Plasmalogens / biosynthesis*,  metabolism,  physiology*
Subcellular Fractions / metabolism
Chemical
Reg. No./Substance:
0/Plasmalogens

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