Document Detail


Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure.
MedLine Citation:
PMID:  20970425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We define cardiomyokines as heart-derived secreted proteins that affect cardiovascular function via autocrine, paracrine and/or endocrine mechanisms. The subject of this review is the cardiomyokine, mesencephalic astrocyte-derived neurotrophic factor (MANF). The expression of MANF is increased in the ischemic heart, in part, through activation of ER stress, a condition that drastically impairs the expression and secretion of most cardiomyokines. This novel function of MANF suggests that it may have important roles in the ER stressed, ischemic heart. Consistent with this are recent findings showing that MANF protects against ischemic damage, and that it is anti-hypertrophic. Accordingly, in light of its function as a potentially secreted cardiomyokine, MANF has translational potential as a novel therapy for ischemic heart disease. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure."
Authors:
Christopher C Glembotski
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-10-21
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  51     ISSN:  1095-8584     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-19     Completed Date:  2012-01-06     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  512-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
The SDSU Heart Institute and the Department of Biology, San Diego State University, San Diego, CA 92182, USA. cglembotski@sciences.sdsu.edu
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Cardiomegaly / drug therapy,  physiopathology*
Endoplasmic Reticulum Stress
Gene Expression
Heart Failure / drug therapy,  physiopathology*
Humans
Molecular Sequence Data
Molecular Targeted Therapy
Nerve Growth Factors / genetics,  physiology*,  secretion
Translational Medical Research
Grant Support
ID/Acronym/Agency:
P01 HL085577/HL/NHLBI NIH HHS; P01 HL085577/HL/NHLBI NIH HHS; R01 HL075573/HL/NHLBI NIH HHS; R01 HL075573-08/HL/NHLBI NIH HHS; R01 HL104535/HL/NHLBI NIH HHS; R01 HL104535/HL/NHLBI NIH HHS; R01 HL104535-02/HL/NHLBI NIH HHS; R01 HL75573/HL/NHLBI NIH HHS; R03 EB011698/EB/NIBIB NIH HHS; R03 EB011698/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/MANF protein, human; 0/Nerve Growth Factors
Comments/Corrections

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