Document Detail


Functionally distinct transmission of human immunodeficiency virus type 1 mediated by immature and mature dendritic cells.
MedLine Citation:
PMID:  17567699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dendritic cells (DCs) potently stimulate the transmission of human immunodeficiency virus type 1 (HIV-1) to CD4(+) T cells. Immature DCs (iDCs) located in submucosal tissues can capture HIV-1 and migrate to lymphoid tissues, where they become mature DCs (mDCs) for effective antigen presentation. DC maturation promotes HIV-1 transmission; however, the underlying mechanisms remain unclear. Here we have compared monocyte-derived iDCs and mDCs for their efficiencies and mechanisms of HIV-1 transmission. We have found that mDCs significantly facilitate HIV-1 endocytosis and efficiently concentrate HIV-1 at virological synapses, which contributes to mDC-enhanced viral transmission, at least in part. mDCs were more efficient than iDCs in transferring HIV-1 to various types of target cells independently of C-type lectins, which partially accounted for iDC-mediated HIV-1 transmission. Efficient HIV-1 trans-infection mediated by iDCs and mDCs required contact between DCs and target cells. Moreover, rapid HIV-1 degradation occurred in both iDCs and mDCs, which correlated with the lack of HIV-1 retention-mediated long-term viral transmission. Our results provide new insights into the mechanisms underlying DC-mediated HIV-1 transmission, suggesting that HIV-1 exploits mDCs to facilitate its dissemination within lymphoid tissues.
Authors:
Jian-Hua Wang; Alicia M Janas; Wendy J Olson; Li Wu
Related Documents :
10639589 - Anti-human immunodeficiency virus type 1 of a two-strand-system targeted to the polypur...
15243629 - Cyclophilin a retrotransposition into trim5 explains owl monkey resistance to hiv-1.
16188979 - Low trbp levels support an innate human immunodeficiency virus type 1 resistance in ast...
19390619 - Compartmentalized human immunodeficiency virus type 1 originates from long-lived cells ...
8918929 - Productive and persistent infection of human thymic epithelial cells in vitro with hiv-1.
8676459 - Resistance of previously infected chimpanzees to successive challenges with a heterolog...
11348709 - Comparison of large-scale mammalian cell culture systems with egg culture for the produ...
19684569 - A technique to simultaneously visualize virus-specific cd8+ t cells and virus-infected ...
23749 - Isolation of sindbis (alphavirus) and leanyer viruses from mosquitoes collected in the ...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-06-13
Journal Detail:
Title:  Journal of virology     Volume:  81     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-09-28     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8933-43     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cells, Cultured
Dendritic Cells / immunology,  ultrastructure,  virology*
Endocytosis
HIV-1 / growth & development*,  physiology
Humans
Lectins, C-Type / physiology
Microscopy, Electron, Transmission
Virus Internalization
Grant Support
ID/Acronym/Agency:
R01 AI068493/AI/NIAID NIH HHS; R01 AI068493/AI/NIAID NIH HHS; R01 AI068493-02/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Lectins, C-Type
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T ce...
Next Document:  Heterosubtypic immunity to influenza A virus infection requires a properly diversified antibody repe...