| Functionalized carbon nanotubes for probing and modulating molecular functions. | |
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MedLine Citation:
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PMID: 20189101 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carbon nanotubes (CNTs) entered the domain of biological research a few years ago, creating a significant amount of interest due to their extraordinary physicochemical properties. The integration of CNT-based strategies with biology necessitates a multidisciplinary approach that requires competences in the diverse fields of chemistry, physics, and life sciences. In the biomedical domain CNTs are extensively explored as novel drug delivery systems for therapy and diagnosis. Additionally, CNTs can also be designed as new tools for modulation of molecular functions, by directly affecting various biological processes or by interaction with bioactive molecules. The aim of this review is to discuss how CNTs can be exploited as new probes for molecular functions. The different sections illustrate various applications of CNTs, including gene silencing, surface cell interactions via glycoproteins, biosensing, intracellular drug delivery using an atomic force microscopy tip-based nanoinjector, modulation of antibody/antigen interaction and enzyme activity, and blocking of ion channels. |
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Authors:
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C?cilia M?nard-Moyon; Kostas Kostarelos; Maurizio Prato; Alberto Bianco |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Chemistry & biology Volume: 17 ISSN: 1879-1301 ISO Abbreviation: Chem. Biol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9500160 Medline TA: Chem Biol Country: United States |
Other Details:
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Languages: eng Pagination: 107-15 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Centre National de la Recherche Scientifique, Institut de Biologie Mol?culaire et Cellulaire, UPR 9021 Immunologie et Chimie Th?rapeutiques, 67000 Strasbourg, France. c.menard@ibmc-cnrs.unistra.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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metabolism Antigens / metabolism Biosensing Techniques Drug Delivery Systems Enzymes / metabolism Glycoproteins / metabolism Ion Channels / metabolism Microscopy, Atomic Force Nanotubes, Carbon / chemistry* RNA, Small Interfering / administration & dosage, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antigens; 0/Enzymes; 0/Glycoproteins; 0/Ion Channels; 0/Nanotubes, Carbon; 0/RNA, Small Interfering |
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