| Functional white-laser imaging to study brain oxygen uncoupling/recoupling in songbirds. | |
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MedLine Citation:
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PMID: 20959852 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Contrary to the intense debate about brain oxygen dynamics and its uncoupling in mammals, very little is known in birds. In zebra finches, picosecond optical tomography with a white laser and a streak camera can measure in vivo oxyhemoglobin (HbO(2)) and deoxyhemoglobin (Hb) concentration changes following physiologic stimulation (familiar calls and songs). Picosecond optical tomography showed sufficient submicromolar sensitivity to resolve the fast changes in the hippocampus and auditory forebrain areas with 250 μm resolution. The time course is composed of (1) an early 2-second-long event with a significant decrease in Hb and HbO(2) levels of -0.7 and -0.9 μmol/L, respectively, (2) a subsequent increase in blood oxygen availability with a plateau of HbO(2) (+0.3 μmol/L), and (3) pronounced vasodilatation events immediately after the end of the stimulus. One of the findings of our study is the direct link between blood oxygen level-dependent signals previously published in birds and our results. Furthermore, the early vasoconstriction event and poststimulus ringing seem to be more pronounced in birds than in mammals. These results in birds, tachymetabolic vertebrates with a long lifespan, can potentially yield new insights, e.g., into brain aging. |
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Authors:
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Stéphane Mottin; Bruno Montcel; Hugues Guillet de Chatellus; Stéphane Ramstein |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-20 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 31 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-04 Completed Date: 2011-03-17 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 393-400 Citation Subset: IM |
Affiliation:
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CNRS, Université de Lyon, Lyon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / anatomy & histology* Brain Chemistry / physiology* Energy Metabolism / physiology Finches / physiology* Hemoglobins / metabolism Lasers Male Oxygen Consumption / physiology* Oxyhemoglobins / metabolism Photons Spectroscopy, Near-Infrared Tomography, Optical / methods* Vasoconstriction / physiology Vasodilation / physiology |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Oxyhemoglobins; 9008-02-0/deoxyhemoglobin |
| Comments/Corrections | |
Comment In:
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J Cereb Blood Flow Metab. 2011 Feb;31(2):391-2
[PMID:
20959853
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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