| Functional and ultrastructural alterations of canine myocardium subjected to very brief coronary occlusions. | |
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MedLine Citation:
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PMID: 8881839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of very brief and recurrent coronary occlusions on myocardial regional shortening and its ultrastructure have been analysed. Ultrasonic crystals were implanted in the left ventricular subendocardium of 23 anaesthetized dogs with the thorax open, to measure the shortening fractions of an ischaemic and a control segment. Twenty 2 min total occlusions were provoked in the left anterior descending coronary artery, with 3 min recovery intervals (reperfusion) between occlusions. The shortening fraction decreased progressively with each occlusion, reaching a value 18.9% lower than the basal after the last ischaemic episode (P < 0.05); 32.3% after 4 h of reperfusion (P < 0.01), and 28.6% after 24 h (P < 0.01). Qualitative and quantitative ultrastructural analysis showed an increase in the mitochondrial volume of the ischaemic tissue (158% vs control, P < 0.001) with significant damage to the cell components (7.7-fold increases vs control mitochondria). These results show that when the myocardium is subjected to very brief and repeated coronary occlusions, there is progressive deterioration of systolic function with structural alterations, mainly at the mitochondrial level. These modifications are still observable 24 h after the end of ischaemic stimulation and could be the cause of transitory and/or chronic systolic dysfunctions in the absence of previous heart attack. |
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Authors:
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F Pomar; J Cosin; M Portoles; M Faura; J Renau-Piqueras; A Hernandiz; F Andres; J L Colomer; B Graullera |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European heart journal Volume: 16 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-12-17 Completed Date: 1996-12-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1482-90 Citation Subset: IM |
Affiliation:
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Hospital LA FE, Centro de Investigación, Valencia, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Disease / pathology*, physiopathology* Dogs Heart / physiopathology* Hemodynamics Microscopy, Electron Myocardial Reperfusion Myocardial Stunning / pathology, physiopathology Myocardium / ultrastructure* Reference Values Systole Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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