| Functional tumor imaging with dynamic contrast-enhanced magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 12720260 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is the acquisition of serial MRI images before, during, and after the administration of an MR contrast agent. Unlike conventional enhanced MRI, which simply provides a snapshot of enhancement at one point in time, DCE-MRI permits a fuller depiction of the wash-in and wash-out contrast kinetics within tumors, and thus provides insight into the nature of the bulk tissue properties. Such data is readily amenable to two-compartment pharmacokinetic modeling from which parameters based on the rates of exchange between the compartments can be generated. These parameters can be used to generate color-encoded images that aid in the visual assessment of tumors. DCE-MRI is used currently to characterize masses, stage tumors, and noninvasively monitor therapy. While DCE-MRI is in clinical use, there are also a number of limitations, including overlap between malignant and benign inflammatory tissue, failure to resolve microscopic disease, and the inconsistent predictive value of enhancement pattern with regard to clinical outcome. Current research focuses on improving understanding of the meaning of DCE-MRI at a molecular level, evaluating macromolecular and targeted contrast agents, and combining DCE-MRI with other physiologic imaging techniques such as positron emission tomography. Efforts to standardize DCE-MRI acquisition, analysis, and reporting methods will allow wider dissemination of this useful functional imaging technique. |
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Authors:
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Peter L Choyke; Andrew J Dwyer; Michael V Knopp |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 17 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-04-29 Completed Date: 2004-01-06 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 509-20 Citation Subset: IM |
Affiliation:
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Department of Radiology, National Institutes of Health, Bethesda, Maryland 20892-1162, USA. pchoyke@nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Contrast Media*
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chemistry Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods*, trends Neoplasms / diagnosis* Neovascularization, Pathologic / diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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