Document Detail

Functional treatments in multiple sclerosis.
MedLine Citation:
PMID:  21455067     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: This review focuses on recent advances in the understanding and management of symptoms and dysfunctions associated with multiple sclerosis (MS).
RECENT FINDINGS: A broad spectrum of dysfunctions associated with MS are under investigation. Research published in the past year and a half addresses gait dysfunction, exercise training, fatigue, bowel/bladder and sexual dysfunction, and sleep disruption. Functional electrical stimulation and strength training have been validated for improvement in gait and motor function. Exercise training has been shown to benefit mood and quality of life scores and to reduce circulating inflammatory cytokine levels. Fatigue remains a challenging problem with incremental improvements in understanding of underlying causes and effective drug therapies offered by recent work. Treatment of bowel, bladder and sexual dysfunction utilizing a variety of modalities has been investigated with some progress.
SUMMARY: In the absence of treatments to reverse neurologic injury due to MS, effective symptom management and functional improvement remain essential to mitigate disability and maintain quality of life. Basic research, as well as controlled clinical trials, in this realm offers promising insights and solutions.
Ardith M Courtney; Wanda Castro-Borrero; Scott L Davis; Teresa C Frohman; Elliot M Frohman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  24     ISSN:  1473-6551     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-08-15     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  250-4     Citation Subset:  IM    
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-8806, USA.
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MeSH Terms
Electric Stimulation Therapy
Exercise Therapy
Fatigue / etiology,  therapy
Multiple Sclerosis / complications,  pathology,  physiopathology*,  therapy*
Neural Conduction / physiology
Neuropsychological Tests
Sleep / physiology
Urinary Bladder, Neurogenic / etiology,  therapy

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