Document Detail

Functional and structural aspects of Helicobacter pylori acidic stress response factors.
MedLine Citation:
PMID:  20960531     Owner:  NLM     Status:  In-Process    
Helicobacter pylori is a striking example of adaptation of a bacterium to a very peculiar niche, the human stomach. Despite being a neutralophile, a sophisticated control of gene expression allows it to live and to proliferate in an environment that cycles from nearly neutral to very acidic. Despite the numerous studies performed on the mechanisms of acid adaptation, the physiological function of a large part of the genes products that are up-regulated or down-regulated is often not clear, in particular in the context of the response of the bacterium to an acidic stress. In this review, we discuss the molecular and functional aspects of some of the proteins that are commonly found overexpressed during the acid stress.
Giuseppe Zanotti; Laura Cendron
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  IUBMB life     Volume:  62     ISSN:  1521-6551     ISO Abbreviation:  IUBMB Life     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888706     Medline TA:  IUBMB Life     Country:  England    
Other Details:
Languages:  eng     Pagination:  715-23     Citation Subset:  IM    
Department of Biological Chemistry, University of Padua, Viale G. Colombo 3, 35121 Padua, Italy.
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