Document Detail


Functional specializations of primary auditory afferents on the Mauthner cells: interactions between membrane and synaptic properties.
MedLine Citation:
PMID:  19941953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Primary auditory afferents are usually perceived as passive, timing-preserving, lines of communication. Contrasting this view, a special class of auditory afferents to teleost Mauthner cells, a command neuron that organizes tail-flip escape responses, undergoes potentiation of their mixed (electrical and chemical) synapses in response to high frequency cellular activity. This property is likely to represent a mechanism of input sensitization as these neurons provide the Mauthner cell with essential information for the initiation of an escape response. We review here the anatomical and physiological specializations of these identifiable auditory afferents. In particular, we discuss how their membrane and synaptic properties act in concert to more efficaciously activate the Mauthner cells. The striking functional specializations of these neurons suggest that primary auditory afferents might be capable of more sophisticated contributions to auditory processing than has been generally recognized.
Authors:
Sebastian Curti; Alberto E Pereda
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-11-23
Journal Detail:
Title:  Journal of physiology, Paris     Volume:  104     ISSN:  1769-7115     ISO Abbreviation:  J. Physiol. Paris     Publication Date:    2010 May-Sep
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-07-29     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  9309351     Medline TA:  J Physiol Paris     Country:  France    
Other Details:
Languages:  eng     Pagination:  203-14     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Auditory Pathways / cytology*
Biophysics
Electric Stimulation / methods
Fishes
Membrane Potentials / physiology*
Models, Neurological
Nerve Net / physiology
Neurons
Neurons, Afferent / physiology*
Reaction Time / physiology
Synapses / physiology*
Synaptic Transmission / physiology*
Grant Support
ID/Acronym/Agency:
DC03186/DC/NIDCD NIH HHS; NS0552827/NS/NINDS NIH HHS; R01 DC003186/DC/NIDCD NIH HHS; R01 DC003186-07/DC/NIDCD NIH HHS; R01 NS052827/NS/NINDS NIH HHS; R01 NS052827-04/NS/NINDS NIH HHS; R56 DC003186/DC/NIDCD NIH HHS; R56 DC003186-12A2/DC/NIDCD NIH HHS
Comments/Corrections

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