Document Detail

Functional significance of the decreased attenuation sign on expiratory CT in pulmonary sarcoidosis : report of four cases.
MedLine Citation:
PMID:  11296199     Owner:  NLM     Status:  MEDLINE    
We describe four patients with proven sarcoidosis and minor pulmonary involvement according to high-resolution CT (HRCT) findings in whom the recently described sign of decreased attenuation on expiratory HRCT scan appeared associated with the reduction of the single-breath diffusing capacity of the lung for carbon monoxide (DLCO) and the DLCO adjusted for alveolar volume. These alterations were, in part, reversible under steroid treatment. Major indexes of airway obstruction (FEV(1)/vital capacity ratio and FEV(1)) were normal, while the maximum expiratory flow at 25% above the residual volume of FVC was reduced. These observations suggest that an expiratory HRCT mosaic pattern and diffusion impairment may be early findings in pulmonary sarcoidosis and may be useful for its detection and follow-up.
P Fazzi; P Sbragia; S Solfanelli; S Troilo; C Giuntini
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  119     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-11     Completed Date:  2001-05-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1270-4     Citation Subset:  AIM; IM    
Cardiac and Thoracic Department, Respiratory Pathophysiology Section, University of Pisa, Italy.
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MeSH Terms
Carbon Dioxide / physiology
Lung / radiography*
Middle Aged
Pulmonary Diffusing Capacity
Respiratory Mechanics
Sarcoidosis, Pulmonary / physiopathology,  radiography*
Tomography, X-Ray Computed*
Reg. No./Substance:
124-38-9/Carbon Dioxide

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