| Functional roles of PC-PLC and Cdc20 in the cell cycle, proliferation, and apoptosis. | |
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MedLine Citation:
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PMID: 20517887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phosphatidylcholine-specific phospholipase C (PC-PLC) is the major enzyme in the Phosphatidylcholine (PC) cycle and is involved in many long-term cellular responses such as activation, proliferation, and differentiation events. Cell division cycle 20 homolog (Cdc20) is an essential cell-cycle regulator required for the completion of mitosis. Our previous studies identified the interaction between PC-PLC and Cdc20. Through the interaction, Cdc20 could mediate the degradation of PC-PLC by Cdc20-mediated ubiquitin proteasome pathway (UPP). In this study, we found that PC-PLC might not be involved in cancer metastasis. Inhibition of PC-PLC by D609 could cause cell proliferation inhibition and apoptosis inhibition in CBRH-7919 cells. Inhibition of PC-PLC could also influence the cell cycle by arresting the cells in G1 phase, and Cdc20 might be involved in these processes. Taken together, in this report, we provided new evidence for the functional roles of PC-PLC and Cdc20 in the cell cycle, proliferation, and apoptosis in CBRH-7919 cells. |
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Authors:
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Zhiwei Chen; Yongfeng Yu; Da Fu; Ziming Li; Xiaoming Niu; Meilin Liao; Shun Lu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell biochemistry and function Volume: 28 ISSN: 1099-0844 ISO Abbreviation: Cell Biochem. Funct. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-02 Completed Date: 2010-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8305874 Medline TA: Cell Biochem Funct Country: England |
Other Details:
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Languages: eng Pagination: 249-57 Citation Subset: IM |
Copyright Information:
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2010 John Wiley & Sons, Ltd. |
Affiliation:
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Shanghai Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiaotong University, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* Bridged Compounds / chemistry, pharmacology Cell Cycle Proteins / metabolism, physiology* Cell Differentiation Cell Line Cell Proliferation* G1 Phase Humans Leupeptins / chemistry, pharmacology Rats Thiones / chemistry, pharmacology Type C Phospholipases / metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Bridged Compounds; 0/Cdc20 protein, rat; 0/Cell Cycle Proteins; 0/Leupeptins; 0/Thiones; 133407-82-6/benzyloxycarbonylleucyl-leucyl-leucine aldehyde; 83373-60-8/tricyclodecane-9-yl-xanthogenate; EC 3.1.4.-/Type C Phospholipases; EC 3.1.4.3/phosphatidylcholine-specific phospholipase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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