Document Detail

Functional residual capacity and total respiratory system impedance in wheezing infants.
MedLine Citation:
PMID:  8090605     Owner:  NLM     Status:  MEDLINE    
Airways obstruction has been demonstrated in acutely wheezing infants. The aim of the present study was to assess functional abnormalities as detected by measurement of total respiratory system resistance (Rrs) and functional residual capacity (FRC) in infants with a history of recurrent episodes of wheezing, while not acutely ill. In 30 such infants (mean age, 10 months; range, 4-17) and in 10 healthy infants (mean age, 6 months; range, 0-14) four Rrs measurements, performed with the forced pseudo-random noise (PRN) oscillation technique, and three FRC determinations, using the closed-circuit helium dilution technique, were averaged. A lower than predicted FRC was demonstrated in 20/30 (66%) patients. At 16 Hz, Rrs was significantly above predicted in 3/30 (10%) patients. Specific Rrs (Rrs x FRC) at 16 Hz was increased in 5/30 (17%) patients. In conclusion, the PRN oscillation technique combined with FRC measurement by helium dilution detects lung function abnormalities in a minority of wheezing infants during symptom-free intervals.
K N Desager; H P Van Bever; M Willemen; W De Backer; P A Vermeire
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  17     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-10-18     Completed Date:  1994-10-18     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  354-8     Citation Subset:  IM    
Department of Respiratory Medicine, University Hospital of Antwerp, Belgium.
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MeSH Terms
Airway Resistance / physiology*
Case-Control Studies
Chloral Hydrate
Functional Residual Capacity / physiology*
Infant, Newborn
Lung / physiology*,  physiopathology
Peak Expiratory Flow Rate
Plethysmography, Whole Body
Pulmonary Ventilation
Regression Analysis
Reproducibility of Results
Respiratory Sounds
Tidal Volume / physiology*
Reg. No./Substance:
302-17-0/Chloral Hydrate; 7440-59-7/Helium

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