Document Detail

Functional residual capacity to thoracic gas volume (FRC:TGV) ratio in healthy neonates.
MedLine Citation:
PMID:  7644774     Owner:  NLM     Status:  MEDLINE    
Gas trapping has been suggested to be common in healthy newborns in the immediate postnatal period. To determine the veracity of that finding, functional residual capacity (FRC) and thoracic gas volume (TGV) were measured in such a population and the FRC:TGV ratios were related to measurements of airway resistance (RAW). FRC was assessed by a helium gas dilution technique, TGV and RAW by plethysmography. Twenty-four healthy infants born at term were studied at a median age of 2 days (range 1-5 days). None had respiratory problems, nor had their mothers undergone invasive antenatal procedures. Their median FRC, which was 27.1 (range 23.8-32.0) ml kg-1, was significantly lower than their TGV (median 29.8, range 26-33 ml kg-1, P < 0.01). The mean 'within subject' difference between FRC and TGV was 2.5 (range 0.3-5.5) ml kg-1. The median FRC:TGV ratio was 0.93 (range 0.82-0.99). Eight infants had an FRC:TGV ratio less than 0.9, two of whom were studied on the first postnatal day. No infant with a low (< 0.9) FRC:TGV ratio had an abnormal RAW. The differences between FRC and TGV demonstrated in this study were smaller than documented in earlier series, suggesting the degree of gas trapping may previously have been over-estimated.
B Yüksel; A Greenough
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiratory medicine     Volume:  89     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-09-18     Completed Date:  1995-09-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  429-33     Citation Subset:  IM    
Department of Child Health, King's College Hospital, London, U.K.
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MeSH Terms
Airway Resistance
Functional Residual Capacity*
Indicator Dilution Techniques
Infant, Newborn / physiology*
Lung Volume Measurements*
Reference Values

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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