| Functional residual capacity and airway resistance of the rat measured with a heat- and temperature-adjusted body plethysmograph. | |
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MedLine Citation:
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PMID: 17134540 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The functional residual capacity (FRC) and airway resistance (R(aw)) of the rat were measured, using a newly designed body plethysmograph (BPG), the inner environment of which was maintained at body temperature and was water-vapor saturated. The subjects were anesthetized and tracheally intubated male Wistar rats (n = 15). After measuring the FRC and R(aw), we analyzed the effects of inhaled methacholine (Mch, 0-8 mg/ml) on R(aw).The determined FRC was 5.37 +/- 0.22 ml (mean +/- SE). An almost linear relationship between box pressure and respiratory flow was obtained when the difference between box-gas temperature and the rectal temperature of the rat was less than 1.0 degrees C. The R(aw) at FRC was 0.230 +/- 0.017 cm H(2)O/ml/s. It increased proportionally with increases in the Mch concentration. When the dynamic changes in R(aw) were analyzed, the R(aw) was found to progressively increase during expiration; this increase continued throughout inspiration. Thus in the rat, R(aw) is not simply a function of changes in lung volume. In conclusion, the humidity- and temperature-adjusted BPG provided an absolute and possibly dynamic value of R(aw). |
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Authors:
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Sakurako Tajiri; Tetsuri Kondo; Hajime Yamabayashi |
Publication Detail:
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Type: Journal Article Date: 2006-12-01 |
Journal Detail:
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Title: The journal of physiological sciences : JPS Volume: 56 ISSN: 1880-6546 ISO Abbreviation: J Physiol Sci Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-27 Completed Date: 2007-04-03 Revised Date: 2008-12-29 |
Medline Journal Info:
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Nlm Unique ID: 101262417 Medline TA: J Physiol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 449-54 Citation Subset: IM |
Affiliation:
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Department of Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259-1193 Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Airway Resistance / drug effects, physiology* Animals Body Temperature / physiology* Bronchoconstriction / drug effects, physiology Bronchoconstrictor Agents / administration & dosage, pharmacology Functional Residual Capacity / physiology Hot Temperature* Humidity Lung / physiology* Male Methacholine Chloride / administration & dosage, pharmacology Plethysmography, Whole Body / methods*, veterinary Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Bronchoconstrictor Agents; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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