Document Detail


Functional remodeling of glutamate receptors by inner retinal neurons occurs from an early stage of retinal degeneration.
MedLine Citation:
PMID:  19350664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Retinitis pigmentosa reflects a family of diseases that result in retinal photoreceptor death and functional blindness. The natural course of retinal changes secondary to photoreceptor degeneration involves anatomical remodeling (cell process alterations and soma displacement) and neurochemical remodeling. Anatomical remodeling predominantly occurs late in the disease process and cannot explain the significant visual deficits that occur very early in the disease process. Neurochemical remodeling includes modified glutamate receptor disposition and altered responses secondary to functional activation of glutamate receptors. We investigated the neurochemical remodeling of retinal neurons in the rd/rd (rd1) mouse retina by tracking the functional activation of glutamate receptors with a cation probe, agmatine. We provide evidence that bipolar cells and amacrine cells undergo selective remodeling of glutamate receptors during the early phases of retinal degeneration. These early neurochemical changes in the rd/rd mouse retina include the expression of aberrant functional ionotropic glutamate receptors on the cone ON bipolar cells from postnatal day 15 (P15), poor functional activation of metabotropic glutamate receptors on both rod and cone ON bipolar cells throughout development/degeneration, and poor functional activation of N-methyl-D-aspartate receptors on amacrine cells from P15. Our results suggest that major neurochemical remodeling occurs prior to anatomical remodeling, and likely accounts for the early visual deficits in the rd/rd mouse retina.
Authors:
Jacqueline Chua; Erica L Fletcher; Michael Kalloniatis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  514     ISSN:  1096-9861     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-04-14     Completed Date:  2009-05-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  473-91     Citation Subset:  IM    
Affiliation:
Department of Optometry and Vision Science, University of Auckland, Private Bag 92010, Auckland, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Agmatine
Animals
Calcium-Binding Protein, Vitamin D-Dependent / metabolism
Cell Count
Glutamic Acid / metabolism
Immunohistochemistry
Mice
Mice, Transgenic
Microscopy, Confocal
Receptors, AMPA / metabolism
Receptors, Glutamate / metabolism*
Receptors, N-Methyl-D-Aspartate / metabolism
Retinal Degeneration / physiopathology*
Retinal Neurons / cytology,  physiology*
Retinitis Pigmentosa / physiopathology
Synapses / metabolism
Vesicular Glutamate Transport Protein 1 / metabolism
Chemical
Reg. No./Substance:
0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Receptors, AMPA; 0/Receptors, Glutamate; 0/Receptors, N-Methyl-D-Aspartate; 0/Slc17a7 protein, mouse; 0/Vesicular Glutamate Transport Protein 1; 0/calretinin; 306-60-5/Agmatine; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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