Document Detail


Functional regeneration of severed peripheral nerve using an implantable electrical stimulator.
MedLine Citation:
PMID:  21096369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper presents functional regeneration of severed peripheral nerve using a polymer-based implantable electrical stimulator. A polyimide based conduit electrode was made by micro-fabrication and a stimulation chip was designed to generate biphasic current pulse for electrical stimulation. The stimulation chip was packaged with a battery using silicone elastomer, and integrated with the electrode. The implantable electrical stimulator was implanted in the rat sciatic nerve with 7 mm gap. The electrical stimulation was applied for periods of one, two and four weeks between the proximal and the distal nerve stumps. After four weeks of post-operations, the degree of regeneration was evaluated through walking track assessments and by measuring neural response of the regenerated nerve. Based on these results, electrical stimulation, especially for two weeks of stimulation, could accelerate functional regeneration of the severed nerve.
Authors:
Tae Hyung Lee; Hui Pan; In Sook Kim; Soon Jung Hwang; Sung June Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2010     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-04-06     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1511-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Electric Power Supplies*
Electric Stimulation Therapy / instrumentation*
Nerve Regeneration*
Prostheses and Implants*
Rats
Recovery of Function*
Sciatic Neuropathy / diagnosis*,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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