| Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation. | |
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MedLine Citation:
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PMID: 15572109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A concept in Parkinson's disease postulates that motor cortex may pattern abnormal rhythmic activities in the basal ganglia, underlying the genesis of observed motor symptoms. We conducted a preclinical study of electrical interference in the primary motor cortex using a chronic MPTP primate model in which dopamine depletion was progressive and regularly documented using 18F-DOPA positron tomography. High-frequency motor cortex stimulation significantly reduced akinesia and bradykinesia. This behavioral benefit was associated with an increased metabolic activity in the supplementary motor area as assessed with 18-F-deoxyglucose PET, a normalization of mean firing rate in the internal globus pallidus (GPi) and the subthalamic nucleus (STN), and a reduction of synchronized oscillatory neuronal activities in these two structures. Motor cortex stimulation is a simple and safe procedure to modulate subthalamo-pallido-cortical loop and alleviate parkinsonian symptoms without requiring deep brain stereotactic surgery. |
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Authors:
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Xavier Drouot; Satoru Oshino; Bechir Jarraya; Laurent Besret; Haruhiko Kishima; Philippe Remy; Julien Dauguet; Jean Pascal Lefaucheur; Frédéric Dollé; Françoise Condé; Michel Bottlaender; Marc Peschanski; Yves Kéravel; Philippe Hantraye; Stéphane Palfi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuron Volume: 44 ISSN: 0896-6273 ISO Abbreviation: Neuron Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-01 Completed Date: 2005-01-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 769-78 Citation Subset: IM |
Affiliation:
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URA CEA-CNRS 2210, Service Hospitalier Frédéric Joliot, 91401 Orsay, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chronic Disease Disease Models, Animal Electric Stimulation Electrophysiology Fluorodeoxyglucose F18 MPTP Poisoning / complications, physiopathology*, radionuclide imaging Motor Cortex / physiopathology*, radionuclide imaging Movement Disorders / etiology, physiopathology Papio Parkinson Disease / physiopathology Positron-Emission Tomography Radiopharmaceuticals Recovery of Function |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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