| Functional recovery and expression of GDNF seen in photochemically induced cerebral infarction. | |
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MedLine Citation:
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PMID: 17365117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor involved in the survival and proliferation of neurons. However, there have been few reports examining the relationship between GDNF and functional recovery after cerebral infarction. The authors investigated the change in the expression of GDNF proteins during functional recovery in rats following photochemically induced cerebral infarctions. Functional recovery for the first 14 days after the infarction was evaluated using a beam-walking test. The number of GDNF-like immunoreactive cells around the infarction were counted at various times (24 h, 72 h, 7 days, and 14 days) post-infarction. Immunohistochemical analysis of brain sections showed that the expression of GDNF-like immunoreactive cells was significantly increased in the temporal cortex until 7 days on the side ipsilateral to the infarction, and had decreased by 14 days. Likewise, the functional recovery of paralysis was substantial until 7 days post-infarction, after which the improvement was mild. Therefore, the expression of GDNF protein might have some relationship with the functional recovery of paralysis. There are great hopes that GDNF could be used as a therapeutic agent for cerebral infarction. |
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Authors:
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Keisuke Horinouchi; Satoshi Ikeda; Katsuhiro Harada; Akihiko Ohwatashi; Yurie Kamikawa; Akira Yoshida; Yoshiko Nomoto; Seiji Etoh; Kazumi Kawahira |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The International journal of neuroscience Volume: 117 ISSN: 0020-7454 ISO Abbreviation: Int. J. Neurosci. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-16 Completed Date: 2007-04-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0270707 Medline TA: Int J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 315-26 Citation Subset: IM |
Affiliation:
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Department of Rehabilitation and Physical Medicine, Graduate school of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Cell Count Cerebral Infarction / chemically induced, metabolism*, physiopathology* Gene Expression Regulation / physiology Glial Cell Line-Derived Neurotrophic Factor / metabolism* Immunohistochemistry / methods Photochemistry / methods Psychomotor Performance / physiology Rats Rats, Wistar Recovery of Function / physiology* Rose Bengal Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Glial Cell Line-Derived Neurotrophic Factor; 11121-48-5/Rose Bengal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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