Document Detail


Functional recovery of diaphragm paralysis: a long-term follow-up study.
MedLine Citation:
PMID:  18276128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Long-term functional outcome of diaphragm paralysis is largely unknown. METHODS: A retrospective study was conducted in 23 consecutive patients (21 males, 56+/-9 years) with uni- or bilateral diaphragm paralysis to examine whether functional respiratory recovery can be predicted from the compound motor action potential (CMAP) of the diaphragm at the time of diagnosis. Pulmonary function and CMAP were evaluated at baseline and at follow-up. CMAP amplitude and latency were recorded by surface electromyography with percutaneous electrical stimulation of the phrenic nerve. Patients were followed for (median) 15 months up to 131 months (range 5-131). Functional respiratory recovery was defined as an increase in forced vital capacity > 400 ml. RESULTS: Functional recovery occurred in 43% of the patients after 12 months (10 out of 23) and in 52% after 24 months (12 out of 23). Type and etiology of paralysis did not influence recovery. CMAP, anthropometric characteristics and baseline pulmonary function did not predict functional respiratory recovery. Whether respiratory muscle training improved pulmonary function is uncertain. Moreover, it did not result in a greater percentage functional respiratory recovery. Relapse after an initial improvement was observed in 26% of the patients. CONCLUSIONS: The present study indicates that functional recovery of diaphragm paralysis is difficult to predict and may occur years after the onset of the paralysis.
Authors:
Ghislaine Gayan-Ramirez; Nadège Gosselin; Thierry Troosters; Frans Bruyninckx; Rik Gosselink; Marc Decramer
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Publication Detail:
Type:  Journal Article     Date:  2008-02-13
Journal Detail:
Title:  Respiratory medicine     Volume:  102     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-03     Completed Date:  2008-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  690-8     Citation Subset:  IM    
Affiliation:
Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, Onderwijs en Navorsing 1 bus 706, Herestraat 49, B-3000 Leuven, Belgium. ghislaine.gayan-ramirez@med.kuleuven.be
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Aged
Diaphragm / physiopathology*
Electric Stimulation
Electromyography
Epidemiologic Methods
Female
Humans
Lung / physiopathology
Male
Middle Aged
Motor Neurons / physiology
Neural Conduction
Phrenic Nerve / physiopathology
Recovery of Function
Respiratory Function Tests
Respiratory Paralysis / physiopathology*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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