| Functional properties of human neuronal Kv11 channels. | |
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MedLine Citation:
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PMID: 19319565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kv11 potassium channels are important for regulation of the membrane potential. Kv11.2 and Kv11.3 are primarily found in the nervous system, where they most likely are involved in the regulation of neuronal excitability. Two isoforms of human Kv11.2 have been published so far. Here, we present a new splice variant that is present in human brain as demonstrated by reverse transcription PCR. Heterologous expression in Xenopus laevis oocytes revealed a 30-mV shift in the voltage dependence of activation to more depolarized potentials and slower activation together with faster deactivation kinetics compared to hKv11.1. Further, we have cloned and electrophysiologically characterized two splice variants of hKv11.3. When expressed in X. laevis oocytes, both isoform 1 and isoform 2 elicited robust currents with a striking transient current component caused by delayed inactivation. The different current characteristics of the isoforms presented in this work may contribute to the regulation of neuronal excitability. |
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Authors:
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Karoline Einarsen; Kirstine Calloe; Morten Grunnet; Søren-Peter Olesen; Nicole Schmitt |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-25 |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 458 ISSN: 1432-2013 ISO Abbreviation: Pflugers Arch. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-01 Completed Date: 2009-09-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: Germany |
Other Details:
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Languages: eng Pagination: 689-700 Citation Subset: IM |
Affiliation:
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The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen N, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology* Animals Cells, Cultured Ion Channel Gating / physiology* Membrane Potentials / physiology* Neurons / physiology* Oocytes / physiology* Potassium Channels / chemistry, genetics, physiology* Xenopus laevis |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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