Document Detail

Functional probing of glucocorticoid receptor structure.
MedLine Citation:
PMID:  3059058     Owner:  NLM     Status:  MEDLINE    
The glucocorticoid receptor (GR) consists of three functional domains. The steroid-binding domain is situated at the C-terminal end and N-terminal sequence analysis has identified the border of this domain at residue 518. The DNA-binding domain is central and lies between residues 414 and 517. The remaining N-terminal half of the protein constitutes the third domain. Probing of the steroid-receptor interaction by affinity-labelling and radiosequence analysis has identified three steroid-binding amino acid residues, Met-622, Cys-656 and Cys-754.
J Carlstedt-Duke; J A Gustafsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of steroid biochemistry     Volume:  31     ISSN:  0022-4731     ISO Abbreviation:  J. Steroid Biochem.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-01-19     Completed Date:  1989-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0260125     Medline TA:  J Steroid Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  593-7     Citation Subset:  IM    
Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, Sweden.
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MeSH Terms
Binding Sites
DNA-Binding Proteins / physiology
Glucocorticoids / metabolism
Molecular Weight
Nuclear Proteins / ultrastructure*
Peptide Hydrolases / metabolism
Receptors, Glucocorticoid / physiology,  ultrastructure*
Regulatory Sequences, Nucleic Acid
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Glucocorticoids; 0/Nuclear Proteins; 0/Receptors, Glucocorticoid; EC 3.4.-/Peptide Hydrolases

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