Document Detail


Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention.
MedLine Citation:
PMID:  11916008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The matrix metalloproteinases appear to play an important role in the development and progression of atherosclerotic lesions. We studied the C-1562T polymorphism of the gelatinase B promoter in relation to coronary artery disease and restenosis after a percutaneous coronary intervention (PCI) in Koreans. To determine the frequency of the C-1562T allele, we examined 63 patients with coronary artery disease who underwent both PCI and 6-month follow-up coronary angiograms (CAGs), and 67 control patients with a normal CAG with respect to their clinical data and genotype. Frequencies of the C/C homozygotes and the non-C/C heterozygotes and homozygotes (C/T and T/T) were 94% and 6% in the normal CAG group, and 76.2% and 23.8% in the patient group, respectively. This gave a relative risk of 0.203 (95% CI: 0.063-0.651, P = 0.005) for coronary artery disease when the C/C genotype was compared with the non-C/C genotype. In the patient groups, the allele frequencies of the C/C and non-C/C were 80% and 20% in the nonrestenotic subgroup, and 71.4% and 28.6% in the restenotic subgroup (P = 0.554). No T/T homozygote was found in any of the groups. We conclude that C/C homozygosity is a potential genetic protective factor for coronary artery disease in Koreans.
Authors:
Hyun-Jai Cho; In-Ho Chae; Kyung-Woo Park; Jae-Ran Ju; Seil Oh; Myoung-Mook Lee; Young-Bae Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of human genetics     Volume:  47     ISSN:  1434-5161     ISO Abbreviation:  J. Hum. Genet.     Publication Date:  2002  
Date Detail:
Created Date:  2002-03-27     Completed Date:  2002-05-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9808008     Medline TA:  J Hum Genet     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  88-91     Citation Subset:  IM    
Affiliation:
Heart Research Institute, Medical Research Center, Seoul National University, Korea.
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MeSH Terms
Descriptor/Qualifier:
Angioplasty, Transluminal, Percutaneous Coronary*
Coronary Artery Disease / enzymology,  genetics*
Coronary Restenosis / enzymology,  genetics*
Female
Humans
Male
Matrix Metalloproteinase 9 / genetics*,  metabolism
Middle Aged
Polymorphism, Genetic*
Promoter Regions, Genetic / genetics*
Chemical
Reg. No./Substance:
EC 3.4.24.35/Matrix Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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