| Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention. | |
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MedLine Citation:
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PMID: 11916008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The matrix metalloproteinases appear to play an important role in the development and progression of atherosclerotic lesions. We studied the C-1562T polymorphism of the gelatinase B promoter in relation to coronary artery disease and restenosis after a percutaneous coronary intervention (PCI) in Koreans. To determine the frequency of the C-1562T allele, we examined 63 patients with coronary artery disease who underwent both PCI and 6-month follow-up coronary angiograms (CAGs), and 67 control patients with a normal CAG with respect to their clinical data and genotype. Frequencies of the C/C homozygotes and the non-C/C heterozygotes and homozygotes (C/T and T/T) were 94% and 6% in the normal CAG group, and 76.2% and 23.8% in the patient group, respectively. This gave a relative risk of 0.203 (95% CI: 0.063-0.651, P = 0.005) for coronary artery disease when the C/C genotype was compared with the non-C/C genotype. In the patient groups, the allele frequencies of the C/C and non-C/C were 80% and 20% in the nonrestenotic subgroup, and 71.4% and 28.6% in the restenotic subgroup (P = 0.554). No T/T homozygote was found in any of the groups. We conclude that C/C homozygosity is a potential genetic protective factor for coronary artery disease in Koreans. |
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Authors:
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Hyun-Jai Cho; In-Ho Chae; Kyung-Woo Park; Jae-Ran Ju; Seil Oh; Myoung-Mook Lee; Young-Bae Park |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of human genetics Volume: 47 ISSN: 1434-5161 ISO Abbreviation: J. Hum. Genet. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-03-27 Completed Date: 2002-05-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9808008 Medline TA: J Hum Genet Country: Japan |
Other Details:
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Languages: eng Pagination: 88-91 Citation Subset: IM |
Affiliation:
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Heart Research Institute, Medical Research Center, Seoul National University, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary* Coronary Artery Disease / enzymology, genetics* Coronary Restenosis / enzymology, genetics* Female Humans Male Matrix Metalloproteinase 9 / genetics*, metabolism Middle Aged Polymorphism, Genetic* Promoter Regions, Genetic / genetics* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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