| Functional polymers for targeted delivery of nucleic acid drugs. | |
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MedLine Citation:
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PMID: 19655399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cationic polymers have been chemically modified with a variety of targeting molecules such as peptides, proteins, antibodies, sugars and vitamins for targeted delivery of nucleic acid drugs to specific cells. Stimuli-sensitive polymers exhibiting different size, charge and conformation in response to physiological signals from specific cells have also been utilized for targeted delivery. To achieve target-specific delivery of nucleic acids, conjugation chemistry is critical to produce stable nanosized polyplexes tethered with cell-recognizable ligands for facile cellular uptake via a receptor-mediated endocytic pathway. In this review, synthetic strategies of functional cationic polymers with various targeting ligands are presented. |
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Authors:
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Hyejung Mok; Tae Gwan Park |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Macromolecular bioscience Volume: 9 ISSN: 1616-5195 ISO Abbreviation: Macromol Biosci Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-11 Completed Date: 2009-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: Germany |
Other Details:
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Languages: eng Pagination: 731-43 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences and the Graduate Program of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Drug Carriers
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chemistry Drug Delivery Systems / methods* Nucleic Acids / administration & dosage* Polymers / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Nucleic Acids; 0/Polymers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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