Document Detail

Functional performance and quality of life in patients with squamous esophageal carcinoma receiving surgery or chemoradiation: results from a randomized trial.
MedLine Citation:
PMID:  21233603     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to compare the 2-year functional performance and quality of life in patients with operable squamous cell carcinoma of the esophagus, who have received either surgery or definitive chemoradiation (CRT).
SUMMARY BACKGROUND DATA: The functional outcomes and quality of life in patients receiving esophagectomy or definitive CRT is uncertain.
METHODS: Data were extracted from the database of a prospective randomized controlled trial that included patients with resectable mid or lower thoracic esophageal cancers. The patients were randomized to either standard esophagectomy or definitive CRT. Quality of life assessments were performed using the EORTC QLQ-C30 and QLQ-OES24 modules. Other functional assessments included pulmonary and eating functions.
RESULTS: From July 2000 to December 2004, a total of 81 patients were enrolled into the study. No significant longitudinal changes were detected in the global health status in both groups upon available follow-up. Surgery was associated with worsened physical functioning and fatigue symptoms up to 6 months after treatment (P < 0.001 and P = 0.021, respectively) and these scales improved at 2 years. In terms of pulmonary function, dyspnoic and coughing symptoms were significantly worsened 3 months after surgery (P = 0.024 and P = 0.036, respectively) whereas symptoms in the CRT group progressively deteriorated over time. Concerning the eating function, both groups had improvements in dysphagia but there were frequent need for endoscopic intervention. This study has been registered with and the ID number is NCT01032967.
CONCLUSION: Neither surgery nor definitive CRT significantly impaired the global health status of patients. Surgery was associated with a short-term negative impact in some aspects of health related quality of life assessments but these changes became insignificant 2 years after treatment. However, CRT was associated with progressive deteriorations in pulmonary function in the longer term.
Anthony Yuen Bun Teoh; Philip Wai Yan Chiu; Tiffany Cho Lam Wong; Shirley Yuk Wah Liu; Simon Kin Hung Wong; Enders Kwok Wai Ng
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Annals of surgery     Volume:  253     ISSN:  1528-1140     ISO Abbreviation:  Ann. Surg.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-14     Completed Date:  2011-02-24     Revised Date:  2014-05-16    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  AIM; IM    
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MeSH Terms
Carcinoma, Squamous Cell / physiopathology,  therapy*
Cohort Studies
Combined Modality Therapy
Esophageal Neoplasms / physiopathology,  therapy*
Quality of Life
Recovery of Function
Treatment Outcome
Comment In:
Ann Surg. 2014 May;259(5):e81   [PMID:  24722224 ]
Ann Surg. 2014 May;259(5):e83   [PMID:  24722225 ]
Ann Surg. 2011 Jan;253(1):6-7   [PMID:  21233604 ]
Ann Surg. 2014 May;259(5):e82   [PMID:  22580934 ]

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