Document Detail


Functional pathology of aldosterone-producing adenoma.
MedLine Citation:
PMID:  6934686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In addition to the morphological examination, the measurement of the content of corticosteroids was done in aldosterone-producing adenoma. Histologically, the adenoma consists of four types of cells. The major component of the adenoma was clear-type cells. In this type of cells, the activities of 3 beta-hydroxysteroid dehydrogenase and glucose-6-phosphate dehydrogenase showed weakly positive. The fine structure was characterized by numerous lipid vacuoles and poor organellae. On the contrary, intermediate- and compact-type cells revealed higher than moderate activities of these enzymes. Moreover, marked development of smooth endoplasmic reticulum and mitochondria was noted. Zona glomerulosa-type cells were observed only in a small part. The content of aldosterone and corticosterone in aldosterone-producing adenoma was significantly larger than those of the other type of adenoma. A tendency of positive correlation between the increase of compact-type cells and content of aldosterone was found. The cell origin of this aldosterone-producing adenoma and functional role of clear- and compact-type cells were also discussed.
Authors:
H Tsuchiyama; K Kawai; T Harada; K Shigematsu; H Sugihara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pathologica japonica     Volume:  30     ISSN:  0001-6632     ISO Abbreviation:  Acta Pathol. Jpn.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-02-26     Completed Date:  1981-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372637     Medline TA:  Acta Pathol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  967-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxysteroid Dehydrogenases / analysis
Adenoma / analysis,  pathology*,  ultrastructure
Adrenal Cortex Hormones / analysis
Adrenal Gland Neoplasms / analysis,  pathology*
Adult
Aldosterone / biosynthesis*
Female
Humans
Hyperaldosteronism / pathology
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 52-39-1/Aldosterone; EC 1.1.-/3-Hydroxysteroid Dehydrogenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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