Document Detail


Functional outcome in young adult ischemic stroke: impact of lipoproteins.
MedLine Citation:
PMID:  22616937     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: To determine the functional outcome in a cohort of young adults with ischemic stroke patients, focusing on components of lipid profile. METHODS: In our registry including consecutive patients with first-ever ischemic stroke aged 15-49 from 1994 to 2007, we analyzed predictors of 3-month functional outcome (modified Rankin Scale, mRS). Infarct size fell into small, medium, large posterior, or large anterior. Stroke severity was assessed with NIH Stroke Scale (NIHSS). Serum lipids were measured within 72 h after admission. Binary, multinomial ordinal, and Poisson regressions allowed revealing factors associated with size of infarct, stroke severity, and unfavorable outcome or death (mRS, 2-6) or mRS as an ordinal measure. RESULTS: In the 968 patients included (mean age, 41.3 ± 7.6; 62.6% men; 49.5% with mRS 0-1), factors associated with unfavorable outcome after multivariable analysis were increasing age (odds ratio, 1.03 per year; 95% confidence interval, 1.01-1.05), higher NIHSS score (1.23 per point, 1.17-1.29), large anterior (4.37, 2.26-8.42) or posterior (1.73, 1.05-2.85) infarcts, bilateral lesions (2.28, 1.30-3.98), internal carotid artery dissection (ICAD) (3.65, 1.41-9.47), and inversely high-density lipoprotein (HDL) levels (0.58 per unit increase, 0.38-0.86). Increasing HDL associated with smaller infarct size (0.71, 0.51-0.98). Both higher total and HDL cholesterol associated with lower NIHSS score (0.96, 0.93-0.98 for total cholesterol and 0.82, 0.75-0.88 for HDL) and lower 3-month mRS (0.87, 0.78-0.97 for total cholesterol and 0.65, 0.47-0.90 for HDL). CONCLUSION: In addition to known prognosticators, ICAD and lower HDL levels were independently associated with adverse clinical outcomes in our young adult stroke cohort.
Authors:
J Putaala; D Strbian; S Mustanoja; E Haapaniemi; M Kaste; T Tatlisumak
Related Documents :
22083587 - Association of coronary artery calcium with severity of myocardial ischemia in left ant...
10150627 - Doppler echocardiography in cardiac tamponade and constrictive pericarditis.
11916607 - Involvement of right ventricle in left ventricular hypertrophic cardiomyopathy: analysi...
18445537 - Echocardiographic evaluation including tissue doppler imaging in new zealand white rabb...
22023697 - Acute left ventricular dysfunction secondary to right ventricular septal pacing in a wo...
8269187 - Reversible left ventricular dysfunction with coronary stenotic or obstructive lesions i...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-23
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  -     ISSN:  1600-0404     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Tobacco smoke exposure and allergic sensitization in children: a propensity score analysis.
Next Document:  Construction of Semisynthetic DNA-Protein Conjugates with Phi X174 Gene A* Protein.